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Research

With a long-term research interest in staphylococcal biology and pathogenesis, our lab focuses on studying virulence factors secretion in S. aureus. Currently, we are investigating the mechanisms supporting septal trafficking of YSIRK/G-S proteins in S. aureus. Proteins with YSIRK/G-S signal peptides are secreted at the septa where staphylococcal cells divide, and are deposited into the cross wall during cell division. Upon cell separation, proteins with YSIRK/G-S signal peptides are distributed over the bacterial surface and fulfills many different virulence functions of the bacteria. The understanding of how these proteins are secreted will form the basis for developing novel therapeutics to combat staphylococcal infections.

Septal trafficking of YSIRK/G-S proteins in S aureus


2019 Wenqi Yu, Rocky D. Bull and USF